250mg Triclabendazole Bolus
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Nā hana lāʻau lapaʻau
ʻO Pharmacodynamics Triclobendazole no ka papa benzimidazole o nā lāʻau lapaʻau, ua hoʻohana kūikawā ʻia e kūʻē i ka Fasciola hepatica, a ua maopopo ka hopena pepehi ʻana iā Fasciola hepatica o nā makahiki like ʻole.lāʻau fluke.Ma hope o ke komo ʻana o ka lāʻau lapaʻau, hoʻopilikia ia i ka ʻōnaehana microtubule a me ka hana o ka parasite, Kāohi i ka hoʻokuʻu ʻana o nā protease hydrolytic parasite.ʻO ka hopena o ka triclobendazole ma nā ilo ʻokoʻa me ka ʻike, e like me nā pākeke ma nā haʻahaʻa haʻahaʻa (1 ~ 3μg/ml)
Ke ola mau nei ka lāʻau lapaʻau no nā hola 24, a ua nāwaliwali loa ka hana i ka ʻike kiʻekiʻe (10-25μg / ml) no nā hola 24;ke kiʻekiʻe o ka 25-50μg/ml e hoʻopau loa iā ia no 24 mau hola.Akā ʻoi aku ka maʻalahi i nā ilo.Ma ka 10 μg / ml, ua kāohi ʻia nā hana 24-hola āpau.
Pharmacokinetics
He kiʻekiʻe ka bioavailability o trilobendazole.Ma hope o ka lawelawe waha o 10 mg / kg ke kaumaha o ke kino i nā kao a me nā hipa, hiki i ka lāʻau plasma kiʻekiʻe i ka 15 μg / ml i 24 a 36 mau hola, a ʻoi aku ka kiʻekiʻe o ke koko o ka trilobendazole a me kāna mau metabolites.ʻO ka waiwai kiʻekiʻe o ka lāʻau lapaʻau he 5 a 20 mau manawa ma mua o nā anthelmintics benzimidazole ʻē aʻe, a ʻo ka hapalua o ke ola he 22 mau hola.ʻO Triclobendazole ka nui o ka oxidized i loko o nā hipa a me nā ʻiole i ka sulfone a me ka sulfoxide derivatives, e hoʻopaʻa i ka albumin a hoʻomau i ka plasma no nā lā ʻoi aku ma mua o 7.ʻO ke kiʻekiʻe o ka plasma kiʻekiʻe a me ka hoʻopaʻa ʻana i ka albumin plasma e pili ana me ka lōʻihi o ka hana o ka antifascioli.Ma hope o 10 mau lā o ka hoʻohana ʻana i ka lāʻau lapaʻau i nā hipa, ma kahi o 95% o ka lāʻau i hoʻokuʻu ʻia i loko o nā feces, 2% i hoʻokuʻu ʻia i loko o ka mimi, a ʻoi aku ka liʻiliʻi o ka 1% i ka waiū.
Nā hana a me nā hoʻohana
ʻO ka lāʻau anti-fasciola benzimidazole.Hoʻohana nui ia no ka pale ʻana a me ka mālama ʻana i ka maʻi Fasciola hepatica i nā pipi a me nā hipa.
Ka hopena ʻino
ʻAʻole i ʻike ʻia nā hopena ʻino i ka wā i hoʻohana ʻia e like me ka hoʻohana ʻana a me ka dosage
Hoʻomalu
(1) Hoʻopau ʻia i ka wā hana waiū.
(2) He mea ʻawaʻawa loa ia i ka iʻa, a ʻaʻole pono e hoʻohaumia ke koena pahu lāʻau i ke kumu wai.
(3) Pono ka poʻe maʻi i nā lāʻau lapaʻau e ʻalo i ka pili ʻana i ka ʻili a me ka inhalation i ka wā e hoʻohana ai, e komo i nā mīkina lima i ka wā e lawe ai i nā lāʻau lapaʻau, a pāpā i ka ʻai ʻana, ka inu ʻana a me ka puhi paka.
(4) Holoi lima ma hope o ka noi ʻana
Ka wā huki
56 lā no nā pipi a me nā hipa
Waihona
E mālama i kahi ma lalo o 30 ℃.
Ua hoʻokumu ʻia ʻo Hebei Veyong pharmaceutical Co., Ltd i ka makahiki 2002, aia ma Shijiazhuang City, Hebei Province, Kina, ma hope o ka Capital Beijing.He ʻoihana lāʻau lapaʻau nui ʻo GMP i hōʻoia ʻia, me ka R&D, ka hana ʻana a me ke kūʻai ʻana i nā API lāʻau holoholona, hoʻomākaukau, premixed feed a me nā mea hoʻohui.Ma ke ʻano he Provincial Technical Center, ua hoʻokumu ʻo Veyong i kahi ʻōnaehana R&D hou no ka lāʻau lapaʻau lāʻau hou, a ʻo ia ka ʻoihana ʻenehana loea e pili ana i ka lāʻau holoholona, aia he 65 mau loea loea.Loaʻa iā Veyong nā kumu hana ʻelua: Shijiazhuang a me Ordos, kahi o ka Shijiazhuang base e uhi i kahi ʻāpana o 78,706 m2, me nā huahana API 13 me Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, a me 11 mau laina hana hoʻomākaukau e pili ana i ka injection, ka hopena waha, ka pauka. , premix, bolus, pesticides and disinfectant, ects.Hāʻawi ʻo Veyong i nā API, ʻoi aku ma mua o 100 mau hoʻomākaukau inoa ponoʻī, a me ka lawelawe OEM & ODM.
Hoʻopili nui ʻo Veyong i ka hoʻokele ʻana o ka ʻōnaehana EHS (Environment, Health & Safety), a loaʻa iā ia nā palapala hōʻoia ISO14001 a me OHSAS18001.Ua hoʻopaʻa inoa ʻia ʻo Veyong i loko o nā ʻoihana ʻoihana e ulu nei i ka ʻāina ʻo Hebei a hiki ke hōʻoia i ka hoʻolako mau ʻana o nā huahana.
Ua hoʻokumu ʻo Veyong i ka ʻōnaehana hoʻokele maikaʻi piha, loaʻa ka palapala ISO9001, China GMP palapala, Australia APVMA GMP palapala, Ethiopia GMP palapala, Ivermectin CEP palapala, a hala ka US FDA inspection.Loaʻa iā Veyong ka hui ʻoihana o ka hoʻopaʻa inoa, kūʻai aku a me ka lawelawe ʻenehana, ua loaʻa i kā mākou hui ka hilinaʻi a me ke kākoʻo mai nā mea kūʻai aku he nui e ka maikaʻi o ka huahana, kiʻekiʻe ma mua o ke kūʻai aku a me ka lawelawe ma hope o ke kūʻai aku, koʻikoʻi a me ka hoʻokele ʻepekema.Ua hana lōʻihi ʻo Veyong me nā ʻoihana lāʻau lapaʻau holoholona i ʻike ʻia ma ka honua me nā huahana i lawe ʻia i ʻEulopa, ʻAmelika Hema, Middle East, ʻApelika, ʻAsia, etc. ma mua o 60 mau ʻāina a me nā ʻāina.
