ʻO Tildipirosin
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ʻO Tildipirosin
ʻO Tildipirosin kahi ʻano hou o semi-synthetic 16-membered ring macrolide antibiotic no nā holoholona, he mea ia o ka tylosin.
Hana lāʻau lapaʻau
ʻO ka hopena antibacterial o Tildipirosin ua like ia me ka tylosin, a he hopena pale ikaika kona i ka maʻi bacteria Gram-positive a me kekahi mau bacteria Gram-negative.ʻO ka hana antibacterial o Tildipirosin ka like me ka macrolides.Hiki iā ia ke hui pū me ka subunit 50S o ka ribosome o nā maʻi maʻi paʻakikī e kāohi i ka synthesis o nā kaulahao peptide riboprotein, a laila e hoʻopili ai i ka synthesis o nā protein bacterial.Hoʻokaʻawale ka pilina o nā ʻāpana piperidine ʻelua i Tildipirosin i ke ʻano o ka hana o kēia lāʻau mai tylosin a me tilmicosin, kahi i kuhikuhi ʻia ai ka 20-piperidine i ka lumen e hoʻopilikia i ka ulu ʻana o nā peptides nascent.
No ka mea he 3 mau pūʻulu amino kumu ka tediroxine, hiki iā ia ke hana i nā ʻano like ʻole ma lalo o nā kūlana pH like ʻole.ʻO ka nui o ka uku ke kumu nui e hoʻopau ai i ka solubility o nā lipid bacteria a komo i ka membrane o waho o ka bacteria Gram-negative, no laila ua hoʻopilikia nui ʻia ka hana bacteriostatic o Tildipirosin in vitro e ka pH.Ma lalo o nā kūlana acidic, ua protonated ka pūʻulu amino, ka hopena i ka emi ʻana o ka hana antibacterial o tediroxine, ʻoiai ma lalo o nā kūlana alkaline, ʻoi aku ka ikaika o ka hana antibacterial.
Kāohi ʻo Macrolides i ka huna ʻana o nā cytokine proinflammatory, ka hana phospholipase, a me ka hoʻokuʻu leukotriene, a loaʻa nā hopena anti-inflammatory i nā macrophages a me nā neutrophils.Hoʻemi ʻo Tediroxine i nā mea hoʻolaha inflammatory i hana ʻia i ka wā o kekahi mau pane ʻeha a koʻikoʻi paha.
ʻĀpana antibacterial
He mea maikaʻi ʻo Tildipirosin e kūʻē i nā bacteria pathogenic e hoʻoulu ai i nā maʻi hanu i nā puaʻa a me nā pipi (e like me Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. , a ʻoi aku ka maikaʻi o ka hana antibacterial e kūʻē i ka ʻōpū Escherichia coli ma mua o tylosin a me tilmicosin.He mea maʻalahi nō hoʻi ia i kekahi mau mycoplasma strains, spirochetes, brucella, etc. Ua hōʻike ʻia nā haʻawina e ʻoi aku ka ikaika o ka tediroxine i ka hopena bacteriostatic ma Haemophilus parasuis a me Bordetella bronchiseptica ma mua o florfenicol, akā nāwaliwali ka hopena bacteriostatic ma Actinobacillus pleuropneumoniae a me Pasteurella multo.He mea bactericidal ka Tildipirosin i kekahi mau ma'i bacteria (e like me Haemophilus parasuis a me Actinobacillus pleuropneumoniae), oiai he mea bacteriostatic ia i kekahi mau bacteria (e like me Pasteurella multocida).No ka maʻi bacteria intestinal, me ka emi ʻana o ka waiwai pH (mai 7.3 a 6.7), ua hoʻonui ʻia ka MIC o Tildipirosin, no ka laʻana, hiki ke hoʻonui ʻia ka MIC o Tildipirosin e kūʻē iā Salmonella Enteritidis a me Escherichia coli mai 2 ~ 8ug/m a 64 ~ 256ug/mL .No laila, pono e noʻonoʻo ʻia ka hopena o ka hoʻololi ʻana o ka pH i ka vivo i ka wā e hana ai i ka hoʻāʻo antibacterial in vivo o Tildipirosin.Eia kekahi, ʻo ka MIC o Tildipirosin e kūʻē i nā ʻano maʻamau o Pasteurella multocida he 0.5ug / mL i ka serum, ʻo ia ka 0.25 mau manawa haʻahaʻa ma mua o ka in vitro, hiki ke pili i ka hopena serum.
ʻO Enterococcus-Streptococcus i loko o nā bipi waiu ke kūpaʻa nui i ka tediroxine.ʻAʻole pili ʻo Tildipirosin iā Pasteurella multocida a me Mannheimia haemolyticus e lawe ana i nā ʻano mutant.Pēlā nō, kūʻē nā ʻano genetically mutated o M. bovis i nā lāʻau antibiotic macrolide me Tildipirosin.Ua ʻike ʻia kekahi mau ʻano o ka Haemophilus parasuis i kū maoli i ka tediroxine.Hiki i ka Mycoplasma bovis ke kū'ē koke iā Tildipirosin, akā ma muli o ka lohi o ka ulu ʻana o Mycoplasma, hiki ke hoʻopaneʻe ka hoʻāʻo ʻana i ka lāʻau lapaʻau in vitro.Ua hōʻike nā haʻawina e pili ana ka domain II (nucleotide 748) a me ka domain V (Mutations in nucleotides 2059 a me 2060) me ka piʻi ʻana o ke kū'ē i nā macrolides.No laila, hiki ke kiʻi koke ʻia ka maʻalahi o M. bovis i nā lāʻau lapaʻau macrolide ma o ka hoʻāʻo ʻana o ka molekala o kēia mutation.
Maʻiʻo
≥ 98%
Hōʻike
Kūlana ʻoihana
Ua hoʻokumu ʻia ʻo Hebei Veyong pharmaceutical Co., Ltd i ka makahiki 2002, aia ma Shijiazhuang City, Hebei Province, Kina, ma hope o ka Capital Beijing.He ʻoihana lāʻau lapaʻau nui ʻo GMP i hōʻoia ʻia, me ka R&D, ka hana ʻana a me ke kūʻai ʻana i nā API lāʻau holoholona, hoʻomākaukau, premixed feed a me nā mea hoʻohui.Ma ke ʻano he Provincial Technical Center, ua hoʻokumu ʻo Veyong i kahi ʻōnaehana R&D hou no ka lāʻau lapaʻau lāʻau hou, a ʻo ia ka ʻoihana ʻenehana loea e pili ana i ka lāʻau holoholona, aia he 65 mau loea loea.Loaʻa iā Veyong nā kumu hana ʻelua: Shijiazhuang a me Ordos, kahi o ka Shijiazhuang base e uhi i kahi ʻāpana o 78,706 m2, me nā huahana API 13 me Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, a me 11 mau laina hana hoʻomākaukau e pili ana i ka injection, ka hopena waha, ka pauka. , premix, bolus, pesticides and disinfectant, ects.Hāʻawi ʻo Veyong i nā API, ʻoi aku ma mua o 100 mau hoʻomākaukau inoa ponoʻī, a me ka lawelawe OEM & ODM.
Hoʻopili nui ʻo Veyong i ka hoʻokele ʻana o ka ʻōnaehana EHS (Environment, Health & Safety), a loaʻa iā ia nā palapala hōʻoia ISO14001 a me OHSAS18001.Ua hoʻopaʻa inoa ʻia ʻo Veyong i loko o nā ʻoihana ʻoihana e ulu nei i ka ʻāina ʻo Hebei a hiki ke hōʻoia i ka hoʻolako mau ʻana o nā huahana.
Ua hoʻokumu ʻo Veyong i ka ʻōnaehana hoʻokele maikaʻi piha, loaʻa ka palapala ISO9001, China GMP palapala, Australia APVMA GMP palapala, Ethiopia GMP palapala, Ivermectin CEP palapala, a hala ka US FDA inspection.Loaʻa iā Veyong ka hui ʻoihana o ka hoʻopaʻa inoa, kūʻai aku a me ka lawelawe ʻenehana, ua loaʻa i kā mākou hui ka hilinaʻi a me ke kākoʻo mai nā mea kūʻai aku he nui e ka maikaʻi o ka huahana, kiʻekiʻe ma mua o ke kūʻai aku a me ka lawelawe ma hope o ke kūʻai aku, koʻikoʻi a me ka hoʻokele ʻepekema.Ua hana lōʻihi ʻo Veyong me nā ʻoihana lāʻau lapaʻau holoholona i ʻike ʻia ma ka honua me nā huahana i lawe ʻia i ʻEulopa, ʻAmelika Hema, Middle East, ʻApelika, ʻAsia, etc. ma mua o 60 mau ʻāina a me nā ʻāina.
